Sex as a Biologic Variable in Preclinical Imaging Research: Initial Observations with 18F-FLT

Conclusion: Depending on whether female or male mice are used, differences in biodistribution and nonspecific tissue uptake can adversely affect quantitative measures of 18F-FLT uptake. Thus, sex is a potential variable to consider in defining quantitative imaging metrics using 18F-FLT to assess tumor proliferation.

Source: Journal of Nuclear Medicine - May 1, 2018 Category: Nuclear Medicine Authors: Chan, S. R., Salem, K., Jeffery, J., Powers, G. L., Yan, Y., Shoghi, K. I., Mahajan, A. M., Fowler, A. M. Tags: Basic Source Type: research