Symptomatic hypercalcemia and scarring alopecia as presenting features of sarcoidosis.
Symptomatic hypercalcemia and scarring alopecia as presenting features of sarcoidosis. Proc (Bayl Univ Med Cent). 2018 Apr;31(2):224-226 Authors: Frieder J, Kivelevitch D, Menter A Abstract Sarcoidosis is a multisystem granulomatous disease most frequently affecting the lungs, lymph nodes, and eyes. Skin involvement occurs in approximately 25% to 35% of cases, with the scalp uncommonly affected. Abnormal calcium metabolism is associated with sarcoidosis and other granulomatous disorders and most commonly presents as hypercalciuria (40%-60%) and, less frequently, hypercalcemia (10%-20%). Symptomatic hypercalcemia is unusual, presenting in 14 mg/dL, 3.5 mmol/L), scarring alopecia, and acute-on-chronic kidney failure. PMID: 29706828 [PubMed]
We report a case with a challenging diagnosis of sarcoidosis with alopecia, erythrodermia, acquired cutis laxa in early aging onset and calciphylaxis.
We previously published a genome-wide association study (GWAS) and meta-analysis to search for common alleles that contribute to risk of AA, and identified several genomic regions harboring potential susceptibility genes. One candidate susceptibility gene expressed in the hair follicle (HF) in AA is peroxiredoxin 5 (PRDX5) (p= of 8.7*10-14), which is also a GWAS gene in Crohn ’s disease, sarcoidosis, and psoriasis. PRDX5 is a member of the family of antioxidant enzymes that are crucial for regulating oxidative stress.
Sarcoidosis is a chronic multisystemic, inflammatory disease with specific granulomatous cutaneous lesions. The cutaneous form may be considered a “great imitator,” due to its extensive clinical morphology that occurs in upwards of 20% to 35% of patients. Cutaneous lesions may have a variety of presentations including papules, plaques, nodules, infiltrative scars, annular, angiolupoid, psoriasiform, hypopigmented, atrophic, ulcerative lesi ons, scarring and nonscarring alopecia, erythroderma, and ichthyosiform lesions.
We report a case of the concurrence of VKHD and sarcoidosis, which may share a common pathophysiology. Accumulation of further similar cases is necessary to elucidate the precise mechanism underlying the concurrence of these two diseases.Case Rep Ophthalmol 2019;10:32 –40
Authors: Prohaska J, Demaree E, Powers J, Cook C Abstract Sarcoidosis is a granulomatous condition that has a highly variable presentation. One rare presentation of sarcoidosis is cutaneous scalp sarcoidosis. Usually scalp sarcoid presents as a scarring alopecia, but it can be nonscarring. The presence of sarcoidal lesions on the scalp is associated with systemic disease, as are other cutaneous manifestations of sarcoidosis. The authors present the case of a 64-year-old woman with a history of sarcoidosis who presented with alopecia and hypopigmented patches on her scalp. She also had papular sarcoid lesions on her...
Publication date: Available online 3 November 2018Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): M. Ishikawa, M. Ohtsuka, T. Yamamoto
PMID: 29857946 [PubMed - as supplied by publisher]
yer N Abstract The development of immune checkpoint inhibitors (monoclonal antibodies targeting PD-1/PD-L1 or CTLA-4) represents a significant advance in the treatment of multiple cancers. Given their particular mechanism of action, which involves triggering CD4+/CD8+ T-cell activation and proliferation, they are associated with a specific safety profile. Their adverse events are primarily immune-related, and can affect practically all organs. In this context, dermatological toxicity is the most common, though it mostly remains mild to moderate and does not require discontinuation of treatment. More than a th...
Abstract Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient‐centered care. To fully appreciate the effect that age may have on the population‐based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project–published data and compared them to similar reports in the worldwide English literature. Using the Rochester Epidemiology Project, populati...
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