Nuclear Whole-Body Bone Scanning for Leprosy.

Nuclear Whole-Body Bone Scanning for Leprosy. Proc (Bayl Univ Med Cent). 2018 Apr;31(2):253 Authors: Joob B, Wiwanitkit V PMID: 29706837 [PubMed]
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research

Related Links:

Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Sakae Yotsumoto Neto, Mayara Ingrid Sousa Lima, Silma Regina Ferreira Pereira, Luiz Ricardo Goulart, Rita de Cássia Silva Luz, Flavio Santos DamosAbstractThe first serum diagnosis of leprosy based on the detection of antibodies of patients using a recombinant mimetic peptide (PGL1M3R) as recognition element and exploiting a photoelectrochemical sensor is presented in this work. The photoeletrochemical platform consists of cadmium sulphide and nickel hydroxide electrodeposited on fluorine-doped tin oxide coated glass slide (C...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
In this report, for the first time, lipid nanostructures coated with polysorbates (Tweens) were formulated by a hot dispersion method. By varying the amount of lipid, type of surfactant, and alcohol, dilution ratio etc., the formulation was optimized with respect to its stability, which is a central aspect of their potential applications. Their comprehensive physicochemical characterization was done using static and dynamic light scattering (SLS, DLS), small angle neutron scattering (SANS), zeta-potential, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and atomic force microscopy (AFM) techniqu...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Abstract Dapsone (DAP) is a bactericidal agent used in the treatment of leprosy, caused by Mycobacterium leprae. Despite its therapeutic potential, DAP has low solubility, which results in allow therapeutic index and a high microbial resistance. Recently, new approaches were used to increase the DAP solubility. In particular, the use of interpenetrating polymer network (IPN)-hydrogels based chitosan (CS) for the controlled release of DAP provides some advantages because they can modify their swelling properties and network structures as a response to environmental stimuli. The aim of this study was to synthesize a...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Conclusions Decrease in cholesterol efflux, increase in uptake, and excess esterification of cholesterol compounded by the action of lipid peroxidation products generated by inflammatory processes contribute to foam cell formation in atherosclerosis. Since these are critical events in the pathogenesis of atherosclerosis, they have been extensively studied. On the contrary, although a role for host lipid metabolism in mycobacterial pathogenesis has been established, research in the different components that contribute to the alteration in host lipid metabolism and cholesterol homeostasis is still in the nascent stages. The...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
ConclusionWe believe that a precise knowledge of the pathology and its management is crucial also for physicians who work in low-incidence countries to maximize healing chances with timely diagnosis and treatment.
Source: Neurological Sciences - Category: Neurology Source Type: research
This article presents a case of treponemic disease in a skeleton of a female adult found at Los Tres Cerros 1 archaeological site (Upper Delta of Paran á River, Entre Ríos, Argentina). This site was occupied by hunter–gatherer–fisher groups that also practised horticulture during the Late Holocene (ca. 1227–560 years BP). A macroscopic description of bone lesions is complemented with data from X‐rays and CT scans. Different types of lesi ons were observed in the left ulna, femora, right patella, tibiae, and fibulae. In addition, two remodelled depressions surrounded by bony thickening...
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
Publication date: November 2018Source: Microbial Pathogenesis, Volume 124Author(s): Mukul Sharma, Madhusmita Das, D. Diana, Anna Wedderburn, Roy AnindyaAbstractMycobacterium leprae is an unculturable obligate pathogen and causative agent for debilitating human disease leprosy. Due to reductive genome evolution M leprae genome harbours large number of pseudogenes and small number of genes (∼1600 genes and ∼1300 pseudogenes). How M leprae remained a successful human parasite with small set of genes remains poorly understood and provided us the impetus to investigate the intergenic regions of M leprae genome for the p...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
This study aimed to identify the distribution pattern of leprosy in a hyperendemic municipality in Brazil and determine its relationship with the clinico-epidemiological situation over 11 years. The geographic information system, MapInfo, spatial scan statistics and the Moran I index were used to analyze new cases. The digital cartographic base was used to map clusters of new paucibacillary and multibacillary cases and cases in minors under 15 years old. Socioeconomic indicators are shown using the choropleth mapping technique. A reduction in the detection coefficient, increases in high-risk spatial clusters, marked change...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
AbstractThe practice of rheumatology in a country like India presents its own unique challenges, including the need to manage patients in a cost-constrained setting, where the lack of uniform government funding for healthcare merits the need to optimize the use of cheaper medicines, as well as devise innovative strategies to minimize the use of costlier drugs such as biologic disease-modifying agents. Use of immunosuppressive agents is also associated with increased risks of infectious complications, such as the reactivation of tuberculosis. In this narrative review, we provide a flavor of such challenges unique to Rheumat...
Source: Rheumatology International - Category: Rheumatology Source Type: research
Conclusion: This study illustrates the potential for applying machine learning to derive a data-driven understanding of the extent to which stigma is prevalent in society. It establishes a framework for the development of an index to track stigma over time and to assist healthcare decision-makers with improving the health of populations and the experience of care for patients. Mental illness constitutes 13 percent of the global burden of disease and is projected to be 15 percent by 2020.1 It affects a significant portion of the United States population. Nearly half of all Americans are estimated to meet the criteria for a ...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review Behavioral health decision tree machine learning social stigma stigma index Source Type: research
More News: Leprosy | PET Scan