Overview of research and therapy facilities for radiobiological experimental work in particle therapy. Report from the European Particle Therapy Network radiobiology group.

Overview of research and therapy facilities for radiobiological experimental work in particle therapy. Report from the European Particle Therapy Network radiobiology group. Radiother Oncol. 2018 Apr 24;: Authors: Dosanjh M, Jones B, Pawelke J, Pruschy M, Sørensen BS Abstract Particle therapy (PT) as cancer treatment, using protons or heavier ions, can provide a more favorable dose distribution compared to X-rays. While the physical characteristics of particle radiation have been the aim of intense research, less focus has been placed on the actual biological responses arising from particle irradiation. One of the biggest challenges for proton radiobiology is the RBE, with an increasing concern that the clinically-applied generic RBE-value of 1.1 is an approximation, as RBE is a complex quantity, depending on both biological and physical parameters, such as dose, LET, cellular and tissue radiobiological characteristics, as well as the endpoints being studied. Most of the available RBE data derive from in vitro experiments, with very limited in vivo data available, especially in late-reacting tissues, which provide the main constraints and influence the quality of life endpoints in radiotherapy. There is a need for systematic, large-scale studies to thoroughly establish the biology of particle radiation in a number of different experimental models in order to refine biophysical mathematical models that can potentially be used to guide PT. The overal...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research

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by Drew Rosielle (@drosielle)A Series of Observations on Opioids By a Palliative Doc Who Prescribes A Lot of Opioids But Also Has Questions.This is the 5th post in a series about opioids, with a focus on how my thinking about opioids has changed over the years. See also:Part 1 – Introduction, General Disclaimers, Hand-Wringing, and a Hand-Crafted Graph.Part 2 – We Were Wrong 20 years Ago, Our Current Response to the Opioid Crisis is Wrong, But We Should Still Be Helping Most of our Long-Term Patients Reduce Their Opioid DosesPart 3 – Opioids Have Ceiling Effects, High-Doses are Rarely Therapeutic, and Ano...
Source: Pallimed: A Hospice and Palliative Medicine Blog - Category: Palliative Care Tags: cancer opioids pain rosielle The profession Source Type: blogs
An artificial intelligence (AI) algorithm for chest x-rays that was tested...Read more on AuntMinnie.comRelated Reading: SIIM: AI can detect, classify TB on chest x-rays CAD software helps stratify risk in lung cancer patients AI outperforms physicians for interpreting chest x-rays Stanford launches huge dataset of chest x-rays for AI Canada-U.S. duo wins RSNA pneumonia AI challenge
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
AbstractRadiation therapy and estrogen deficiency can damage healthy bone and lead to an increased fracture risk. The goal of this study is to develop a mouse model for radiation therapy using a fractionated biologically equivalent dose for cervical cancer treatment in both pre- and postmenopausal women. Thirty-two female C57BL/6 mice 13 weeks of age were divided into four groups: Sham  + non-irradiated (SHAM + NR), Sham + irradiated (SHAM + IRR), ovariectomy + non-irradiated (OVX + NR) and ovariectomy + irradiated (OVX&thinsp...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
Today’s clinicians are limited to a few imaging modalities, primarily X-ray, CT, MRI, and ultrasound. Microwaves, in principle, can also be used as a useful way to look inside the body. Microwave radiation is non-ionizing, so should be safer th...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiology Diagnostics Materials Neurology Oncology Pathology Radiology Source Type: blogs
CONCLUSIONS: Study results indicate that PET/CT staging and treatment effect associate well with SUVmax and immunohistochemical results of tumor, while SUVmax of tumor associates well with tumor size. PMID: 31561405 [PubMed - as supplied by publisher]
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research
CONCLUSION: We concluded that GNPs could act as a good sensitizing agent in RT+US irradiation and could result in the synergistic effects. PMID: 31559711 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Abstract Low-kV IORT is an increasing modality for breast cancer treatment. Soft X-rays from INTRABEAM (Carl Zeiss Meditec AG, Oberkochen, Germany), a dedicated IORT device along with special spherical applicators are employed for this purpose. A Monte Carlo model of INTRAMBEAM and spherical applicators are introduced in the current study to evaluate the dosimetric and physical characteristics of emitted X-rays from the bare probe and different applicator diameters. X-ray probe and different applicator diameters of 1.5cm to 5cm were simulated by GEANT4 Monte Carlo Toolkit. Then, the validity of the simulated model...
Source: Zeitschrift fur Medizinische Physik - Category: Radiology Authors: Tags: Z Med Phys Source Type: research
Smoke-measuring smart shirts, breath sound analyzing algorithms, and smart inhalers pave the way of pulmonology and respiratory care into the future. As the number of patients suffering from asthma, COPD, or lung cancer due to rising air pollution and steady smoker-levels will unfortunately not decrease any time soon, we looked around what technology can do to help both patients and caregivers. The results are breathtaking. Attacks of breathlessness are too common The diseases which pulmonologists and respiratory care specialists attempt to fight are among the most common conditions in the modern world – and t...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence Future of Medicine Health Sensors & Trackers AI asthma cancer cancer treatment care COPD diagnostics inhaler lung lung cancer management medical specialty pulmonology respiratory respiratory care Source Type: blogs
M. Coley An increased rate of cellular proliferation is a hallmark of cancer and may be accompanied by an increase in ribosome biogenesis and dysregulation in rRNA synthesis. In this regard, CX-5461 has been developed as a novel RNA polymerase I inhibitor and is currently in Phase I/II clinical trials for solid and hematological malignancies. In the present study, interactions between CX-5461 and single-dose X-ray exposure were assessed using isobologram analysis using MTS assay and drug-induced cell death was assessed using flow cytometric, confocal microscopy and Western blot analysis. Combination treatments involvi...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Radiation therapy (RT) is one of the most common and efficient treatments of cancer, and it makes use of ionising radiation to cause lethal damage to the tumoral cells by damaging the cellular DNA. The efficacy of RT can be increased if the tumour is previously loaded with high atomic number (Z) compounds and then irradiated with X-rays in the kiloelectronvolt energy range. In this case, the local dose deposition is enhanced because the effective Z of the tumour is increased compared to the adjacent tissues.
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: Original paper Source Type: research
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