Monash study exposes key tactic used by deadly fungus

(Monash University) Associate Professor Ana Traven, in collaboration with the Naderer lab, has found that a lethal fungus destroys the immune cell that would ordinarily kill it, by stealing its source of nutrients. Candida albicans is a microscopic fungus commonly found in the body but which can become a dangerous infection in vulnerable hospital patients. The study demonstrated that the fungus competes with disease-fighting macrophages by rapidly consuming glucose and causing the macrophages to die.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Source: Biotechnology Progress - Category: Biotechnology Authors: Tags: RESEARCH ARTICLE Source Type: research
Publication date: Available online 15 March 2019Source: Food Research InternationalAuthor(s): Bin He, Haoran Li, Zhihong Hu, Yihan Zhang, Min Sun, Shangkun Qiu, Bin ZengAbstractDouchi has attracted people's attention because of its unique taste and rich health function. The microbes participated in the koji-making process contribute to taste compounds of Douchi. However, the majority of studies on Douchi focused on their functional components and the microbial community in single type of Douchi during koji-making so far. In the present study, the taste components of Mucor-type and Aspergillus-type Douchi were measured init...
Source: Food Research International - Category: Food Science Source Type: research
Authors: Hosseini SS, Ghaemi E, Koohsar F Abstract Background and Objectives: The aim of this study was to determine the effect of zinc oxide nanoparticle (ZnO-np) solution in the surface catheter on C. albicans adhesion and biofilm formation. Materials and Methods: Out of 260 isolates from urinary catheter, 133 were determined as C. albicans by common phenotypic and genotyping methods. ZnO nanoparticles with 30 nm were made by the sol-gel method, which was confirmed by XRD (X-ray diffraction) and scanning electron microscope (SEM) methods. Candidal adhesion and biofilm assays were performed on catheter surface...
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
ConclusionsStudies of the anti-Candida activity of P. tetramera extracts led to the selection of PtDEb as the most suitable extract, confirming the antifungal properties of the threatened species P. tetramera. The new data give a valuable reason for the definitive protection of this sp. and its natural environment thus allowing further studies for the future development of an Herbal Medicinal Antifungal Product.Graphical Abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Abstract OBJECTIVE: As an approach to prevent biofilm infections caused by Candida tropicalis on various surfaces, determination of effect of biodegradable polycaprolactone nanofibers (PCLNFs) with different concentrations of two different essential oils were tested in this study. RESULTS: Both of the tested essential oils exhibited antifungal effect (minimal inhibitory concentration; 0.25-0.49 µL/mL, minimal fungicidal concentration; 0.25-0.49 µL/mL, depending on the C. tropicalis strain) (Zone of inhibition caused by 500 μL/mL concentration of oils; 28-56 mm). 0, 2, 4% clove oi...
Source: Biotechnology Letters - Category: Biotechnology Authors: Tags: Biotechnol Lett Source Type: research
Publication date: Available online 15 March 2019Source: Biochemical Engineering JournalAuthor(s): Chunyu Zhang, Yang Liu, Yan SunAbstractWe recently reported that Candida rugosa lipase (CRL) bonded on zwitterionic polymer-grafted silica nanoparticles (SNPs-pOD-CRL) showed remarkably enhanced catalytic activity and substrate affinity. The polymer, pOD, with long cetane side chains, was a polymer derivative of poly(maleic anhydride-alt-1-octadecene) and N,N-dimethylethylenediamine. Here, a new zwitterionic polymer with shorter alkyl side chains was synthesized by reaction between poly(isobutylene-alt-maleic anhydride) and N,...
Source: Biochemical Engineering Journal - Category: Biochemistry Source Type: research
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Manasés González-Cortazar, Valentín López-Gayou, Jaime Tortoriello, Blanca E. Domínguez-Mendoza, Ada M. Ríos-Cortes, Raúl Delgado-Macuil, Elías E. Hernández-Beteta, Ever A. Blé-González, Alejandro ZamilpaAbstractThe bioassay-guided fractionation of the hydroalcoholic extract from aerial parts of Bacopa procumbens (Mill.) Greenm., allowed to isolate the known phenolic compound arbutin (1) as well as three new gastrodin derivatives which were denominated procumgastrodin A...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
A biocatalytic cascade process was developed using immobilized cells of the wild type yeast Candida albicans CCT 0776 in calcium alginate beads and a commercially available ketoreductase. The aim was to promote deracemization by stereoinversion of ( ±)-1-arylethanols in high substrate concentration (above 100 mmol L-1) to prepare the (R)-enantiomers of the alcohols (90-99%), with a high enantiomeric excess (83-99%) after 2 to 19 h. The (R)-1-(3-methoxyphenyl)ethanol, with 70% yield and 91% ee, obtained after 5 h was used to prepare (S)-1-(3-me thoxyphenyl)-ethylamine with 60% yield and 91% ee after two steps, a key ...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
In conclusion, our findings indicate that mtSSBs can adopt different oligomeric states, ranging from stable tetramers to stable dimers, and suggest that a dimer of mtSSB may be a physiologically relevant species that binds to ssDNA in some yeast species.
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Biophysics Source Type: research
ConclusionNo obvious cause of fungal empyema could be found except for pancreatico-pleural spread as suggested by amylase rich pleural effusion along with growth of candida spp. Hence in patient with chronic pancreatitis and cystgastrostomy pleural effusion should be evaluated for fungal infection to avoid morbidity and mortality and commence early treatment.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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