XXIV World Congress of Asthma
XXIV World Congress of AsthmaDate: Tuesday, May 1, 2018Year: 2018Location: Tokyo, JapanContent-type: current_conferences
Aspergillus fumigatus is a ubiquitous ascomycete mould that can cause a wide spectrum of clinical syndromes. The pathological effects of A. fumigatus depend largely on the interplay between the pathogen and host immune response ranging from asymptomatic colonisation to life-threatening infection. Invasive aspergillosis (IA), the most severe form of A. fumigatus infection, predominantly affects immunocompromised patients. In contrast, immune hyperactivity can lead to allergic bronchopulmonary aspergillosis (ABPA) and fungal sensitization in severe asthma (SAFS).
Allergy,Volume 0, Issue ja, -Not available-.
Wednesday, July 18, 2018 - 13:05Slide presentation
ConclusionThis study indicated that the incidence of airborne fungi with clinical significance had a direct relationship with the variation of environmental conditions.
This study suggests that IgE may play a role in bronchial hyperreactivity associated to A. fumigatus exposure in mice. Mice sensitized and challenged with this fungus showed characteristics of severe asthma, with an increase of BALF neutrophils, histological changes consistent with severe asthma and an increase of IgE capable of triggering type I hypersensitivity.
Publication date: March 2018Source: Journal de Mycologie Médicale, Volume 28, Issue 1Author(s): H. Trablesi, I. Hadrich, S. Neji, N. Fendri, D. Ghorbel, F. Makni, H. Ayadi, S. Kammoun, A. AyadiSummaryThe aim of the present study was to investigate the epidemiological and fungal environmental profile in asthmatic patients. We conducted a prospective study involving 49 patients with allergic asthma. One hundred and forty-five clinical samples and 289 environmental samples were performed. Only 30 patients accepted to participate to the environmental study at their home. For specific IgE antibodies, ELISA assay was cond...
Conclusion: It can be said that the knowledge may help to create a mapping of allergens in this area and help to treat patients by immunotherapy or avoidance strategy.