Pink1 −/− Rats Show Early-Onset Swallowing Deficits and Correlative Brainstem Pathology

AbstractParkinson disease (PD) compromises oropharyngeal swallowing, which negatively affects quality of life and contributes to aspiration pneumonia. Dysphagia often begins early in the disease process, and does not improve with standard therapies. As a result, swallowing deficits are undertreated in the PD population. ThePink1−/− rat is used to model PD, and demonstrates widespread brainstem neuropathology in combination with early-onset sensorimotor dysfunction; however, to date, swallowing behaviors have not been evaluated. To test the hypothesis thatPink1−/− rats demonstrate early-onset differences in swallowing, we analyzed within-subject oropharyngeal swallowing using videofluoroscopy.Pink1−/− and wildtype (WT) controls at 4 (Pink1−/−n = 16, WT = 16) and 8 (Pink1−/−n = 12, WT = 12) months of age were tested. The average and maximum bolus size was significantly increased inPink1−/− rats at both 4 and 8 months. Bolus average velocity was increased at 8 months for all animals; yet,Pink1−/− animals had significantly increased velocities compared to WT at 8 months. The data show a significant reduction in mastication rate forPink1−/− rats at 8 months suggesting the onset of oromotor dysfunction begins at this time point. Relationships among swallowing variables and neuropathological findings, such as incr...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

Related Links:

Abstract Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are important causes of hospital admission and mortality. Pneumonia is a major contributor to hospitalization for AECOPD and has a close relationship with poor outcomes. We performed a prospective cohort study to evaluate the prognosis of AECOPD patients with or without community-acquired pneumonia (CAP) who hospitalized from January 2012 to December 2015. We investigated mortality and readmission rates within 6 months after the first admission between two groups and analyzed the difference of survival rate according to readmission dura...
Source: Chronic Respiratory Disease - Category: Respiratory Medicine Authors: Tags: Chron Respir Dis Source Type: research
Objectives: To identify, appraise, and synthesize current evidence to determine whether early enteral nutrition alters patient outcomes from major burn injury. Data Sources: Medline, Embase, and the China National Knowledge Infrastructure were searched. The close out date was May 1, 2018. Study Selection: Early enteral nutrition was defined as a standard formula commenced within 24 hours of injury or admission to ICU or burn unit. Comparators included any form of nutrition support “except” early enteral nutrition. Only randomized controlled trials reporting patient-centered outcomes were eligible for in...
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Review Articles Source Type: research
Objectives: Subarachnoid hemorrhage is a life-threatening disease associated with high mortality and morbidity. A substantial number of patients develop systemic inflammatory response syndrome. We aimed to identify risk factors for systemic inflammatory response syndrome development and to evaluate the role of systemic inflammatory response syndrome on patients’ outcome. Design: Retrospective observational cohort study of prospectively collected data. Setting: Neurocritical care unit at a tertiary academic medical center. Patients: Two-hundred and ninety-seven consecutive nontraumatic subarachnoid hemorrha...
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research
AbstractIntroductionThe most effective and concurrently the safest treatment regimen selection is important to provide early control of juvenile idiopathic arthritis (JIA) and to have an acceptable quality of life. The effectivity of biologic agents as well as standard disease-modifying drugs is well documented in treatment of JIA. In spite of their high benefit, these drugs have the risk of serious infections. Herein, we conducted a prospective study to investigate the infectious complications of biologic agents in patients diagnosed with JIA.MethodsPatients on biologic treatment regimen were examined by the pediatric inf...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Letter to the Editor Source Type: research
Authors: Huh HJ, Lim KR, Ki CS, Huh K, Shim HJ, Song DJ, Kim YJ, Chung DR, Lee NY Abstract BACKGROUND: Real-time PCR is more sensitive than microscopic examination for detecting Pneumocystis jirovecii. We compared the performance of two assays for detecting P. jirovecii DNA: the RealStar Pneumocystis jirovecii PCR Kit 1.0 CE (Altona Diagnostics, Hamburg, Germany) and the AmpliSens Pneumocystis jirovecii (carinii)-FRT PCR kit (InterLabService Ltd., Moscow, Russia). METHODS: We used 159 samples from the lower respiratory tract (112 bronchoalveolar lavage [BAL] fluid, 37 sputum, and 10 endotracheal aspirate [ETA] ...
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
Vapotherm said today it closed its initial public offering, raising a total $64.4 million in gross proceeds. The Exeter, N.H.-based company developed the Precision Flow line of devices to provide high-velocity heated, humidified and oxygenated air to treat patients with conditions such as pneumonia, chronic obstructive pulmonary disease, asthma and heart failure. Some 1,200 of the devices have been sold in the U.S., mostly into hospital ICUs, the company said. Vapotherm said it floated 4.6 million shares of its common stock at $14 per share, and that the offering featured a fully exercised underwriter’s option to pur...
Source: Mass Device - Category: Medical Devices Authors: Tags: Business/Financial News Initial Public Offering (IPO) Respiratory Wall Street Beat Vapotherm Source Type: news
An artificial intelligence (AI) algorithm written by a Canadian radiologist...Read more on AuntMinnie.comRelated Reading: RSNA launches AI challenge to detect pneumonia on x-rays RSNA names editor for new online journal RSNA to offer educational AI events RSNA foundation to award $4M in grants RSNA plans AI course in Paris
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Smoke masks. Eye drops. No outdoor exercise. This is how Californians are trying to cope with wildfires choking the state, but experts say an increase in serious health problems may be almost inevitable for vulnerable residents as the disasters become more commonplace. Research suggests children, the elderly and those with existing health problems are most at risk. Short-term exposure to wildfire smoke can worsen existing asthma and lung disease, leading to emergency room treatment or hospitalization, studies have shown. Increases in doctor visits or hospital treatment for respiratory infections, bronchitis and pneumonia i...
Source: JEMS: Journal of Emergency Medical Services News - Category: Emergency Medicine Authors: Tags: Patient Care News Source Type: news
ConclusionsBoth an intensive care system and surveillance support should be established to prevent infections, particularly in high-risk patients at LTCHs.
Source: Asian Nursing Research - Category: Nursing Source Type: research
More News: Brain | Neurology | Pathology | Pneumonia | Speech-Language Pathology