MiR-98 suppresses the effects of tumor-associated macrophages on promoting migration and invasion of hepatocellular carcinoma cells by regulating IL-10.

In conclusion, miR-98 not only regulated expression of inflammatory cytokines in HCC-conditioned TAMs, but also modulated the capacity of HCC-conditioned TAMs to regulate HepG2 cell migration and invasion, at least in part, by targeting IL-10. As a result, miR-98 may suppress the progress of HCC. PMID: 29702181 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29702181?dopt=Abstract

Source: Biochimie - April 24, 2018 Category: Biochemistry Authors: Lei L, Pengfei S, Chengsheng Z, Zongchao L, Wuyuan Z Tags: Biochimie Source Type: research