Differential effects of lipophilic and hydrophilic statins on muscle sympathetic nerve activity in heart failure with preserved left ventricular ejection fraction

Augmented sympathetic nerve activity is associated with heart failure with preserved left ventricular ejection fraction (HFpEF). Lipophilic statins reduce sympathetic nerve activity in patients with heart failure with reduced left ventricular ejection fraction. However, little is known about whether all types of statins, regardless of solubility, reduce sympathetic nerve activity in HFpEF. We evaluated the effect of atorvastatin, a lipophilic statin, and rosuvastatin, a hydrophilic statin, on muscle sympathetic nerve activity (MSNA) in HFpEF patients.

Source: Autonomic Neuroscience: Basic and Clinical - April 28, 2018 Category: Neuroscience Authors: Hideki Tokuhisa, Hisayoshi Murai, Yoshitaka Okabe, Takuto Hamaoka, Hiroyuki Sugimoto, Yusuke Mukai, Oto Inoue, Shin-ichiro Takashima, Takeshi Kato, Soichiro Usui, Hiroshi Furusho, Shuichi Kaneko, Masayuki Takamura Source Type: research