A novel voxel based homogeneity index: Rationale and clinical implications for whole-brain radiation therapy.

CONCLUSION: Higher sensitivity and feasibility to assess treatment plan quality using the VHI were demonstrated. First clinical implications were found in terms of compromised OS/CNS PFS for WBRT with radiation underdosage. PMID: 29699833 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research

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AbstractPurposeIt has been accepted that radiation therapy (RT) for ductal carcinoma in situ (DCIS) has no survival benefit despite increasing local control. However, a recent large database study reported a small but significant benefit. Using a Korean population-based large database, we examined the survival benefit of RT for DCIS after breast-conserving surgery (BCS) and analyzed which subgroup might derive benefit from it.MethodsData from 6038 female DCIS patients who underwent BCS with or without RT between 1993 and 2012 were included in this study. We used propensity score analysis to control for differences in basel...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Purpose of review The aim of this study was to review studies published within the past year regarding management of gastric cancer. Recent findings Laparoscopic gastrectomy achieves equivalent survival compared with open gastrectomy in early stage and locally advanced gastric cancer. Adjuvant chemotherapy with 6 months of S-1 and oxaliplatin was superior to 12 months of S-1, and the addition of postoperative radiation therapy did not improve survival. The FLOT regimen is the new standard for preoperative chemotherapy. In metastatic gastric cancer, the addition of docetaxel to S-1 and cisplatin failed to improve overa...
Source: Current Opinion in Gastroenterology - Category: Gastroenterology Tags: STOMACH AND DUODENUM: Edited by Mitchell L. Schubert Source Type: research
You led me away from home just to save you from being alone... you stole my hypofractionation and that's a pain I can do without. (And in the UK? Sounds like a 45er.) Sir Rod Stewart had to go to a London hospital every day for three months to receive radiation therapy and luckily for the singer the treatment... No prostate hypofx for celebs?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
ConclusionMPNST are difficult to manage because of their aggressive nature and the limitations in early diagnosis and management. In patients with Von Recklinghausens disease, malignancy must be suspected when a patient presents with the complaints as mentioned in this case report.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Conditions:   Oropharynx Cancer;   Oropharynx Squamous Cell Carcinoma;   Carcinoma, Squamous Cell;   Carcinoma;   Oropharyngeal Neoplasms;   Neoplasms, Squamous Cell;   Neoplasms, Glandular and Epithelial;   Neoplasms by Histologic Type;   Pharyngeal Neoplasms Malignant and Unspecif ied;   Otorhinolaryngologic Neoplasms;   Head and Neck Neoplasms;   Neoplasms by Site;   Otorhinolaryngologic Diseases;   Pharyngeal Diseases...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Background: Slipped capital femoral epiphysis (SCFEs) can be idiopathic or atypical (associated with renal failure, radiation therapy, and endocrine disorders). It is important to estimate the likelihood that atypical SCFE shows different clinical and radiographic characteristics and complications with typical SCFEs. Methods: We retrospectively reviewed 53 patients (66 hips) with SCFEs managed between 1995 and 2016. Sex, age, weight, height, the duration of symptoms the laterality of the slip, and complications were recorded. Bilateral hip and lower extremity long bone radiographs were utilized to record slip angle, g...
Source: Journal of Pediatric Orthopaedics - Category: Orthopaedics Tags: Hip Source Type: research
AbstractRadiation therapy (RT) is a crucial part of cancer care, but previous work suggests that many non-radiation oncologist physicians are uncomfortable referring for RT. To evaluate training and understanding of RT, the authors sent invitations to complete an online questionnaire to all physicians at a community hospital in Bronx, NY, which asked about oncology training and self-rated and objective knowledge of RT. Out of 247 invited participants, 87 responded (35%). Among responders, 19 were attending physicians (22%) and 66 (76%) were residents. Seventy-two percent of respondents reported caring for>  5 can...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
This article also highlights the role of multidisciplinary involvement in management of extremity skeletal metastasis.
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
AbstractPurpose/objective(s)Data from Darby et al. demonstrated that cardiac dose in patients undergoing breast radiation therapy is associated with cardiac events. Cardiac dose is primarily dependent on treatment laterality and treatment fields. More recently, techniques such deep inspiratory breath hold (DIBH) and prone positioning have been used as cardiac sparing techniques. The purpose of this study is to assess changes in cardiac dosimetry with cardiac sparing techniques.Materials/methodsThis retrospective study included breast cancer patients treated from 2010 to 2018 at a single institution. Mean heart dose (MHD) w...
Source: Journal of Radiation Oncology - Category: Cancer & Oncology Source Type: research
ConclusionThis study confirms the efficacy and safety of SBRT for unresectable liver metastases. Selection of cases may improve survival and LC.
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
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