Maternal nicotine exposure has severe cross-generational effects on offspring behavior.
In this study, female and male mice were exposed respectively by nicotine before pregnancy. The maternal pre-pregnancy nicotine exposure led to depression-like behaviors in the F1 offspring. However, after biparental pre-pregnancy nicotine exposure, seventy percentage of the offspring exhibited a depressive phenotype while 20% were hyperactive, and the remaining exhibited no obvious abnormal behavior. The cross-generational effects appeared to be mediated via disruption of the balance between GSK3 and p-GKS3 by nicotine. These results suggested that pre-pregnancy nicotine exposure can induce alterations in the behavior of the offspring, and the cross-generational effects of maternal nicotine exposure were particularly serious.
PMID: 29698694 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Zhang M, Xu W, He G, Zhang D, Zhao X, Dai J, Wu J, Cao Y, Wang Z, Wang L, Qiao Z Tags: Behav Brain Res Source Type: research
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