PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.

PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.
Cell Mol Life Sci. 2018 Apr 25;:
Authors: Hapak SM, Rothlin CV, Ghosh S
Abstract
Polarity is a fundamental feature of cells. Protein complexes, including the PAR3-PAR6-aPKC complex, have conserved roles in establishing polarity across a number of eukaryotic cell types. In neurons, polarity is evident as distinct axonal versus dendritic domains. The PAR3, PAR6, and aPKC proteins also play important roles in neuronal polarization. During this process, either aPKC kinase activity, the assembly of the PAR3-PAR6-aPKC complex or the localization of these proteins is regulated downstream of a number of signaling pathways. In turn, the PAR3, PAR6, and aPKC proteins control various effector molecules to establish neuronal polarity. Herein, we discuss the many signaling mechanisms and effector functions that have been linked to PAR3, PAR6, and aPKC during the establishment of neuronal polarity.
PMID: 29696344 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - April 25, 2018 Category: Cytology Authors: Hapak SM, Rothlin CV, Ghosh S Tags: Cell Mol Life Sci Source Type: research