Liver- master and servant of serum proteome
In the endoplasmic reticulum (ER), hepatocytes synthesize the majority of serum proteins and this production is adjusted by complex local and systemic regulatory mechanisms. Accordingly, serum levels of hepatocyte-made proteins constitute important biomarkers that reflect both systemic processes and the status of the liver. For example, C-reactive protein is an established marker of inflammatory reaction, whereas transferrin emerges as a liver stress marker and an attractive mortality predictor.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Deniz Kuscuoglu, Sabina Janciauskiene, Karim Hamesch, Johannes Haybaeck, Christian Trautwein, Pavel Strnad Tags: Review Source Type: research