Dissonance among treatment algorithms for hyperglycemia in type 2 diabetes: an egalitarian dialog
In conclusion, the data identified the IRE1α-Xbp1 signaling pathway as an essential mediator that associates EX-4 with the intracellular mechanism that inhibits ER stress and activates Akt in order to regulate β cell survival. This may provide important evidence for the use of EX-4 in treatments for type 2 diabetes. PMID: 30112049 [PubMed]
Publication date: Available online 17 August 2018Source: Neuroscience LettersAuthor(s): Yingli Jing, Mingming Liu, Fan Bai, Di Li, Degang YangAbstractPatients with spinal cord injury (SCI) have an increased risk for developing type 2 diabetes. It is unknown whether the pancreatic-islet microvascular vasomotion is involved. We used female C57BL/6 mice and a 100-kilodyne T10 Infinite Horizons contusion SCI (or T10 laminectomy) to detect blood glucose and pancreatic-islet microvascular vasomotion. Blood glucose obtained from tail vein was detected using one Touch UltraEasy glucometer. Glucose tolerance test was performed by D...
Child health experts say the rise is "alarming" and more should be done to reduce obesity.
Publication date: Available online 17 August 2018Source: American Journal of Preventive MedicineAuthor(s): Tannaz Moin,, Julie A. Schmittdiel,, James H. Flory,, Jessica Yeh,, Andrew J. Karter,, Lydia E. Kruge,, Dean Schillinger,, Carol M. Mangione,, William H. Herman,, Elizabeth A. Walker,ContextPrediabetes is prevalent and significantly increases lifetime risk of progression to type 2 diabetes. This review summarizes the evidence surrounding metformin use for type 2 diabetes prevention.Evidence acquisitionArticles published between 1998 and 2017 examining metformin use for the primary indication of diabetes prevention ava...
Treatment with glucose-lowering therapy does not maintain or improve pancreatic beta-cell function in young people recently diagnosed with impaired glucose tolerance or type 2 diabetes mellitus, a study has shown.
CONCLUSION: In this study, pancreatic steatosis was significantly associated with DR in non-obese patients with T2DM. Further studies are necessary to clarify the causal relationship between pancreatic steatosis and the development of DR. PMID: 30113148 [PubMed - as supplied by publisher]
Authors: Park SY, Chin SO, Rhee SY, Oh S, Woo JT, Kim SW, Chon S Abstract BACKGROUND: Carotid artery intima medial thickness (IMT), brachial-ankle pulse wave velocity (baPWV), and ankle-brachial index (ABI) are commonly used surrogate markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The cardio-ankle vascular index (CAVI) is a complement to the baPWV, which is affected by blood pressure. However, it is unclear which marker is the most sensitive predictor of atherosclerotic cardiovascular disease (ASCVD). METHODS: This was a retrospective non-interventional study that enrol...
CONCLUSION: Men with lower SES had higher odds of having diabetic retinopathy and uncontrolled hyperglycemia, showing the need to improve care targeted to this population. PMID: 30113143 [PubMed - as supplied by publisher]
CONCLUSION: A substantial number of subjects with NFG at baseline still remained in the NFG range at the time of diabetes diagnosis. A family history of diabetes and fasting insulin and glucose levels were associated with diabetes diagnosis during 10 years of follow-up; however, fasting glucose level was not associated with diabetes risk within the relatively short-term follow-up period of 5 years in subjects with NFG. PMID: 30112879 [PubMed - as supplied by publisher]
Authors: Kim KS, Park SW, Cho YW, Kim SK Abstract BACKGROUND: To evaluate the prevalence of chronic kidney disease (CKD) and progression rate to CKD in elderly patients with type 2 diabetes mellitus (T2DM). METHODS: We investigated the medical records of 190 elderly patients (65 years or older) with T2DM from 2005 to 2011 in 6-month increments. Mean follow-up duration was 64.5 months. CKD was defined as estimated glomerular filtration rate (eGFR)