Multi-tissue DNA Methylation Age: Molecular Relationships and Perspectives for Advancing Biomarker Utility.

Multi-tissue DNA Methylation Age: Molecular Relationships and Perspectives for Advancing Biomarker Utility. Ageing Res Rev. 2018 Apr 23;: Authors: Nwanaji-Enwerem JC, Weisskopf MG, Baccarelli AA Abstract The multi-tissue DNA methylation estimator of chronological age (DNAm-age) has been associated with a wide range of exposures and health outcomes. Still, it is unclear how DNAm-age can have such broad relationships and how it can be best utilized as a biomarker. Understanding DNAm-age's molecular relationships is a promising approach to address this critical knowledge gap. In this review, we discuss the existing literature regarding DNAm-age's molecular relationships in six major categories: animal model systems, cancer processes, cellular aging processes, immune system processes, metabolic processes, and nucleic acid processes. We also present perspectives regarding the future of DNAm-age research, including the need to translate a greater number of ongoing research efforts to experimental and animal model systems. PMID: 29698722 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research