Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis.

CONCLUSIONS: Ergometrine plus oxytocin combination, carbetocin, and misoprostol plus oxytocin combination were more effective for preventing PPH ≥ 500 mL than the current standard oxytocin. Ergometrine plus oxytocin combination was more effective for preventing PPH ≥ 1000 mL than oxytocin. Misoprostol plus oxytocin combination evidence is less consistent and may relate to different routes and doses of misoprostol used in the studies. Carbetocin had the most favourable side-effect profile amongst the top three options; however, most carbetocin trials were small and at high risk of bias.Amongst the 11 ongoing studies listed in this review there are two key studies that will inform a future update of this review. The first is a WHO-led multi-centre study comparing the effectiveness of a room temperature stable carbetocin versus oxytocin (administered intramuscularly) for preventing PPH in women having a vaginal birth. The trial includes around 30,000 women from 10 countries. The other is a UK-based trial recruiting more than 6000 women to a three-arm trial comparing carbetocin, oxytocin and ergometrine plus oxytocin combination. Both trials are expected to report in 2018.Consultation with our consumer group demonstrated the need for more research into PPH outcomes identified as priorities for women and their families, such as women's views regarding the drugs used, clinical signs of excessive blood loss, neonatal unit admissions and breastfeeding at discharge. To date, tri...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research

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Abstract not provided as this is a short communication.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Short communication Source Type: research
AbstractPurpose of ReviewCardiovascular disease (CVD) is the leading cause of death among women in the USA, accounting for one of every three deaths. Physical activity (PA) has been shown to have numerous beneficial effects for CVD risk reduction in women. Nonetheless, much of the previous research on the impact of PA on CVD risk factors has been measured using self-report questionnaires. The purpose of this review was to summarize the main findings for the association between objectively measured PA and PA interventions on traditional and nontraditional CVD risk factors from randomized controlled trials (RCT), cohort, and...
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
Condition:   Hypertension, Pregnancy-Induced Interventions:   Drug: Furosemide 20 MG;   Drug: Placebo Oral Tablet Sponsor:   University of Pennsylvania Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: Second trimester MPV and serum uric acid alone or in combination could be used as a useful biochemical markers for prediction of PE based on their validity, simplicity, and availability. PMID: 29893156 [PubMed - as supplied by publisher]
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
This study examines racial/ethnic, nativity, and sociodemographic variations in the prevalence of maternal hypertension in the United States. The 2014-2015 national birth cohort data (N = 7,966,573) were modeled by logistic regression to derive unadjusted and adjusted differentials in maternal hypertension consisting of both pregnancy-related hypertension and chronic hypertension. Substantial racial/ethnic differences existed, with prevalence of maternal hypertension ranging from 2.2% for Chinese and 2.9% for Vietnamese women to 8.9% for American Indians/Alaska Natives (AIANs) and 9.8% for non-Hispanic blacks. Compared wit...
Source: International Journal of Hypertension - Category: Cardiology Tags: Int J Hypertens Source Type: research
Abstract Women with hypertensive pregnancy complications are at greater risk of developing cardiovascular disease (CVD), metabolic diseases, stroke, and end-stage renal disease later in life. Pregnancy complications not only effect the mother's long-term health, but also the health of the fetus immediately after delivery and into adulthood. The health of the fetus until adulthood can be influenced by developmental programming, in which the fetus is exposed to insults that will ultimately affect the growth of the offspring and increase the offspring's risk of developing hypertension, coronary heart disease, metabol...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research
Teen pregnancy and birth rates in the United States remain among the highest of industrialized nations, with approximately 25% of girls becoming pregnant before age 20 [1]. Early diagnosis of pregnancy in this age group is of utmost importance. Adolescents are at an increased risk for many complications during pregnancy such as high blood pressure, anemia, having low birthweight babies and premature birth, and adolescents also tend to have lower rates of prenatal care [2, 3]. Delayed or absence of prenatal care for pregnant adolescents has been shown to correlate with higher rates of preterm birth, increased infant mortali...
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Source: Hypertension - Category: Cardiology Authors: Tags: High Blood Pressure, Hypertension, Preeclampsia Brief Reviews Source Type: research
Source: Hypertension - Category: Cardiology Authors: Tags: Epidemiology, Obesity, Pregnancy, Risk Factors, High Blood Pressure Editorial Commentaries Source Type: research
Hypertensive disorders in pregnancy harm both maternal and infant health and have been linked to ambient particulate matter. However, existing studies are restricted to a local scale and remain inconsistent. A large-scale study is required to enrich the epidemiological evidence and explore the potential sources of the inconsistency. Making use of US birth certificates (1999–2004), and monitoring data from the environmental protection agency air quality networks, we associated hypertensive disorders in pregnancy with maternal exposure to fine particles or coarse particles using logistic regression analysis after adjus...
Source: Hypertension - Category: Cardiology Authors: Tags: Epidemiology Original Articles Source Type: research
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