Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis.

CONCLUSIONS: Ergometrine plus oxytocin combination, carbetocin, and misoprostol plus oxytocin combination were more effective for preventing PPH ≥ 500 mL than the current standard oxytocin. Ergometrine plus oxytocin combination was more effective for preventing PPH ≥ 1000 mL than oxytocin. Misoprostol plus oxytocin combination evidence is less consistent and may relate to different routes and doses of misoprostol used in the studies. Carbetocin had the most favourable side-effect profile amongst the top three options; however, most carbetocin trials were small and at high risk of bias.Amongst the 11 ongoing studies listed in this review there are two key studies that will inform a future update of this review. The first is a WHO-led multi-centre study comparing the effectiveness of a room temperature stable carbetocin versus oxytocin (administered intramuscularly) for preventing PPH in women having a vaginal birth. The trial includes around 30,000 women from 10 countries. The other is a UK-based trial recruiting more than 6000 women to a three-arm trial comparing carbetocin, oxytocin and ergometrine plus oxytocin combination. Both trials are expected to report in 2018.Consultation with our consumer group demonstrated the need for more research into PPH outcomes identified as priorities for women and their families, such as women's views regarding the drugs used, clinical signs of excessive blood loss, neonatal unit admissions and breastfeeding at discharge. To date, tri...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research

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ConclusionA differential diagnosis of digestive system neoplasm should be considered when a pregnant patient presents with gestational diabetes mellitus and disseminated intravascular coagulation, where the disseminated intravascular coagulation has no specific cause and cannot be readily resolved.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Conclusion: A MedDiet, enhanced with EVOO and nuts, was associated with a risk reduction of CMFOs in over 50% in normoglycemic pregnant women. Therefore, it might be a potentially adequate diet for pregnant women.Trial registration: Identifier ISRCTN84389045. The study was registered on September 27, 2013. Last edited on September 26, 2018Ann Nutr Metab 2019;74:69 –79
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
Here is a discussion I first posted in my Wheat Belly Total Health book, chapter 7: Grainless Living Day-to-Day. Glycemic index, or GI, describes how high blood sugar climbs over 90 minutes after consuming a food compared to glucose. The GI of a chicken drumstick? Zero: No impact on blood sugar. How about three fried eggs? Zero, too. This is true for other meats, oils and fats, seeds, mushrooms, and non-starchy vegetables. You eat any of these foods and blood sugar doesn’t budge, no glycation phenomena follow, no glucotoxic or lipotoxic damage to such things as your pancreas. There is nothing intrinsically wrong...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates blood sugar gi gluten-free glycemic grain-free grains Inflammation insulin low-carb Source Type: blogs
Conclusion BPA and TCS urinary concentrations were not associated with GH or preeclampsia; however, our results suggest an association between TCS and GH in nulliparous women. Additional studies are required to confirm our results. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
This study examined the prevalence and temporal trends in (a) pulmonary hypertension (PH) during pregnancy and (b) mortality and morbidity during pregnancy with and without PH.Methods This was a retrospective observational study of the 2003 –2014 New York State Inpatient Database. PH was categorized as primary or secondary and pregnancy as loss or termination of pregnancy, preterm birth, or term birth. The Centers for Disease Control and Prevention definition of maternal morbidity was used, including 17 diagnoses and 5 procedures. Ch anges were assessed using Cochran-Armitage trend tests.Results Of 2,940,868 pregnanc...
Source: Maternal and Child Health Journal - Category: Health Management Source Type: research
Conclusions: A high index of suspicion is needed to diagnose paraganglioma in a pregnant patient with hypertension. Laparoscopic tumor removal for paraganglioma seems to be a feasible and safe procedure during pregnancy.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
A doctor should monitor high blood pressure (hypertension) during pregnancy to prevent complications for the mother, such as preeclampsia, and the baby. High blood pressure is usually treatable and preventable. Learn about the types, causes, and treatments of high blood pressure during pregnancy here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Pregnancy / Obstetrics Source Type: news
This study aimed to assess the relationship between RLS and medical problems among pregnant women. In this study, 700 pregnant women were recruited. A socio-demographic questionnaire and the International Restless Legs Questionnaire were used to gather information. Data analyzed using an independentt test, Chi-square, and multivariate analysis. The prevalence of RLS was 28.9%. Women with hypertension were 1.90 times more probable to have RLS (adjusted OR 1.90, CI 1.14 –3.19). Women with chronic hypertension and superimposed preeclampsia were 2.39 and 2.13 times more probable to experience RLS, respectively. Pre-eclam...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
ConclusionsThe results support feasibility and effectiveness of a lifestyle intervention after complicated pregnancies to improve maternal cardiometabolic risk factors. Further randomized controlled studies are needed with longer follow-up to evaluate durability. In the meantime, we suggest health care professionals to offer lifestyle interventions to women after complicated pregnancies.FundingThis study was funded by ZonMW (61200024).
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: Available online 10 December 2018Source: Pregnancy HypertensionAuthor(s): Yuwen Wen, Linrui Peng, Ruoting Xu, Nailiang Zang, Qitao Huang, Mei ZhongAbstractPurposeThe aim of this study was to compare the levels of trimethylamine-N-oxide (TMAO) in sera of normal and preeclamptic pregnancies and to explore whether serum TMAO level was associated with the severity of preeclampsia.Materials and MethodsEighty-six pregnant women in the third trimester were enrolled in the present case control study. Levels of TMAO were quantified by a novel liquid chromatography/tandem mass spectrometry-based method in fasting s...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
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