CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis

Non-alcoholic fatty liver disease (NAFLD) describes a range of conditions caused by the accumulation of fat in hepatocytes. Fifteen percent to 30% of the general population in both the Western world and Asia suffer from NAFLD [1,2]. The prevalence is increased in type 2 diabetes mellitus (T2DM) (70%) and morbid obesity (90%) [3]. Non-alcoholic steatohepatitis (NASH) is a subset of NAFLD characterized by excessive fat accumulation in hepatocytes (steatosis) associated with liver tissue inflammation.

Source: Journal of Hepatology - April 26, 2018 Category: Gastroenterology Authors: Lei Zhao, Chang Zhang, Xiaoxiao Luo, Pei Wang, Wei Zhou, Shan Zhong, Yunxia Xie, Yibo Jiang, Ping Yang, Renkuang Tang, Qin Pan, Andrew R. Hall, Tu Vinh Luong, Jiangao Fan, Zac Varghese, John F. Moorhead, Massimo Pinzani, Yaxi Chen, Xiong Z. Ruan Source Type: research