Malaria: Clues to vaccine design

Nature Reviews Drug Discovery 17, 316 (2018). doi:10.1038/nrd.2018.57 Author: Sarah Crunkhorn Vaccination with attenuated Plasmodium falciparum sporozoites (PfSPZs) can induce robust immune responses. However, the specific mediators of this protective immune response remain undefined. To investigate this, Seder and colleagues first isolated monoclonal antibodies directed against the Pf circumsporozoite protein (PfCSP) — which covers the
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research