Type 2 diabetes: Targeting glutamine metabolism

Nature Reviews Drug Discovery 17, 316 (2018). doi:10.1038/nrd.2018.56 Author: Sarah Crunkhorn Reducing elevated glucagon signalling in diabetic patients is an attractive strategy for the treatment of hyperglycaemia. Using mouse primary hepatocytes, Miller and colleagues demonstrate a key contribution of glutamine to newly synthesized glucose in response to glucagon stimulation. Short hairpin RNA-mediated knockdown of hepatic glutaminase
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research