Type 2 diabetes: Targeting glutamine metabolism
Nature Reviews Drug Discovery 17, 316 (2018).
doi:10.1038/nrd.2018.56
Author: Sarah Crunkhorn
Reducing elevated glucagon signalling in diabetic patients is an attractive strategy for the treatment of hyperglycaemia. Using mouse primary hepatocytes, Miller and colleagues demonstrate a key contribution of glutamine to newly synthesized glucose in response to glucagon stimulation. Short hairpin RNA-mediated knockdown of hepatic glutaminase
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Sarah Crunkhorn Tags: Research Highlight Source Type: research