Neurodegeneration: New strategy for SBMA therapy

Nature Reviews Drug Discovery 17, 316 (2018). doi:10.1038/nrd.2018.55 Author: Sarah Crunkhorn Spinal bulbar muscular atrophy (SBMA) results from a polyglutamine expansion in the androgen receptor (AR). Recently, co-regulator binding through the activation function 2 (AF2) domain of the AR has been indicated as essential for pathogenesis. Here, Badders and colleagues screened a panel of small molecules
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research