Metabolic disease: Liver enzyme inflames fat

Nature Reviews Drug Discovery 17, 315 (2018). doi:10.1038/nrd.2018.59 Author: Sarah Crunkhorn Obesity-induced activation of adipose tissue inflammation is closely correlated with insulin resistance, but the mechanisms mediating such pathological inflammation are poorly understood. Writing in Nature, Tabas, Ozcan and colleagues report that in mice, obesity stimulates hepatocytes to secrete the enzyme dipeptidyl peptidase 4 (DPP4),
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research