132 IL-33 - T regulatory cell axis triggers development of a cancer-promoting immune environment in chronic inflammation

Chronic inflammation is a well-characterized driver of cancer in the skin and other epithelial organs; however, the mechanism underlying the development of cancer-promoting chronic inflammation is unknown. We previously showed chronic allergic contact dermatitis (ACD) is a type 2 inflammatory disease and potent inducer of squamous cell carcinoma in mice and humans. In contrast, acute ACD, a common skin inflammatory condition, is marked by type 1 inflammation, including T helper 1, cytotoxic T, and NK cells, which inhibit cancer development.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research