216 Master regulators of immune infiltrate recruitment improve efficacy of immune checkpoint inhibitor therapy in melanomas

Immunotherapies are emerging as promising avenues for cancer treatment. The treatment paradigm of immune checkpoint inhibition specifically restores a host ’s ability to recognize and destroy tumors. However, despite their overall promise, a majority of patients do not benefit from treatments. Patients with immunologically “cold” tumors bear mutations rendering immunotherapies ineffective. We previously derived an immune infiltrate recruitment tr anscriptional signature from the hair follicle in alopecia areata (AA), that was controlled by a single network-inferred master regulator (MR), IKZF1.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research