460 Non-histaminergic itch mediators elevated in the skin of human scabies patients and a porcine model of scabies
Unbearable itch is the most common symptom of scabies infestations, which affects more than 100 million people worldwide. However, the underlying pruritic mechanism is not well understood. The expression levels of several known itch mediators (histamine, TRPV1, TRPA1, tryptase, PAR2, and B-tubulin for epidermal nerve quantification) were examinded in scabies-infested and control skin of human subjects and a pig model. Skin biopsies from 6 scabies patients, 4 healthy volunteers, and 3 pigs (one infected ear and contralateral control ear) underwent immunohistochemistry.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: L. Nattkemper, J. Rosen, K. Sanders, H. Andersent, J. Hsiang, C. Bernigaud, J. Guillot, O. Chosidow, G. Yosipovitch Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research