909 Kallikrein 6 (KLK6) mediated keratin 10 degradation is required for VZV propagation in skin

The skin is a tough tissue resistant to damage and therefore refractory to viral propagation. Varicella Zoster Virus (VZV) is a skin-tropic virus that causes chickenpox. Although very common, VZV infection can be life-threatening particularly in the immunocompromised. Therefore, understanding VZV-keratinocyte interactions is important to find new treatments beyond vaccination and anti-viral drugs. In VZV-infected skin, we observed focal up-regulation of the protease Kallikrein 6 (KLK6), and the ubiquitin-ligase MDM2 concomitant with Keratin 10 down-regulation.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research