922 HIV-1 trans-infection of T-cells via dendritic cells requires endosomal sorting and polarized trafficking to the virological synapse

Dendritic cells (DC) are the 'sentinels' of the immune system and play an essential role in the presentation of antigenic material to T-cells. Human Immunodeficiency Virus 1 (HIV-1) is taken into DC evading degradation and transported to a virological synapse (VS) to promote T-cell infection. DC studies have led to the identification of several restriction factors that aid viral transmission, however how the virus is trafficked through the cell to the VS within DC is still unclear. A high-throughput siRNA method was developed in monocyte derived dendritic cells (MDDC) to identify membrane trafficking proteins involved in the transfer of HIV-1 from DC to T-cells.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research