1260 CDK1 phosphorylates Sox2 and enhances tumor initiation and stemness in human melanoma

Tumors consist of diverse cell populations with different tumorigenic capacities, phenotypes and functions. This tumor heterogeneity is a hallmark of cancer and drives disease progression. However, the genes associated with highly tumorigenic subpopulations and their mechanism or regulation remain elusive. We analyzed patient-derived xenografts from melanoma, colon and pancreatic cancer tissues to isolate subpopulations with increased tumor initiating potential and identify their underlying gene signature.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research