1317 Nicotinic acid suppresses sebaceous lipid synthesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2)

Nicotinic acid (NA) is widely used in the clinical practice in treating dyslipidemias. Since NA influences lipid metabolism, and its side effects include skin dryness, we asked if it also impacts on the biology of sebocytes, the professional lipidogenic cells of the human skin. By using human, immortalized SZ95 sebocytes, we found that non-cytotoxic ( ≤100 μM; MTT, DilC1(5)-SYTOX Green) concentrations of NA had no effect on the basal sebaceous lipogenesis (SLP; Nile Red), but normalized several lipogenic agent (arachidonic acid, anandamide and linoleic acid+testosterone)-induced, excessive, acne-mimicking SLP in course of 24-48-hr treatments.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research