1318 Both lesional and non-lesional skin from acne patients shows robust IL-17-skewing and upregulation of antimicrobial peptides

Acne vulgaris is the most prevalent inflammatory skin disease in young age, however its immune pathogenesis is still being elucidated. Only few prior acne studies evaluated skin lesions, largely focusing on a limited panel of markers and/or lacking normal controls. The lack of comprehensive evaluations of all inflammatory axes involved in acne is hindering targeted-therapeutic development for acne. Our study profiles the molecular and cellular profiles of acne in mild-to-moderate patients (n=56), compared to aged-matched controls (n=20), using immunohistochemistry and gene expression studies on lesional, nonlesional, and healthy skin biopsies.There were significant infiltrates of CD3+ T-cells, CD8+ T-cells, and CD11c+ dendritic cells, and neutrophils in lesional but also in nonlesional skin from patients vs.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research