1448 Development of immune-competent human skin constructs to model inflammatory skin diseases
The prevalence of inflammatory skin diseases in United States is 11%, suggesting that approximately 1 in 10 people suffer from an inflammatory skin disease. Most drug development for these diseases is conducted using animal models or 2D cell culture systems, which make it difficult to predict patient-specific drug responses. Here, we developed new 3D skin models for psoriasis and vitiligo by combining skin components together with disease-relevant immune cell populations. We isolated T cells from peripheral blood mononuclear cells (PBMCs) of psoriasis patients and incorporated them into healthy control derived 3D skin constructs to reproduce patient-specific psoriatic inflammation.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: J. Shin, H. Abaci, Z. Guo, F. Magrelli, A. Pappalardo, Y. Doucet, J. Jackow, A. Christiano Tags: Tissue Regeneration and Wound Healing Source Type: research