Chest Wall Resection for Recurrent Breast Cancer Chest Wall Resection for Recurrent Breast Cancer

The utility of full-thickness chest wall resection for recurrent breast cancer has been debated. Is it time for a new way of thinking?Annals of Surgery
Source: Medscape Today Headlines - Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news

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DR. SUKAMAL SAHA (Flint, Michigan): One of the things you commented in your paper was that the type of reconstruction did not affect recurrence. But as I looked through your data, there were many types of implants and reconstruction … pedicle flap, free flap, and tissue expander. How many had free flap, which takes six, 8 h, compared to tissue expander or pedicle flap, and did that make a difference? In your data, there is at least a trend from 20% for tissue expander to 27% for flap with implant to 30% for flap, I don't kn ow what kind of flap.
Source: American Journal of Surgery - Category: Surgery Source Type: research
DR. FAAIZA VAINCE (Maywood, Illinois): Dr. Burkheimer and colleagues, your analysis was thorough and thoughtful. It looked at many variables that are often overlooked when collecting data for the patient population of interest in this discussion.
Source: American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 15 February 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Eman M. Hassan, Ahmed Mohamed, Maria C. DeRosa, William G. Willmore, Yuki Hanaoka, Toshihiko Kiwa, T. OzakiAbstractWe demonstrate high-sensitivity detection of metastatic breast cancer cells using terahertz (THz) chemical microscopy (TCM) with aptamers as ligands. For the aptamers, we use previously developed synthetic single stranded (ss) DNA aptamers mammaglobin B1 (MAMB1) and mammaglobin A2 (MAMA2) that bind to mammaglobin B and mammaglobin A proteins, respectively, which are overexpressed on the surface of MCF7 and MD...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
In this study, we screened extracts and ingredients from five Qi-tonifying herbs exhibiting an inhibitory effect on M2 polarization of murine macrophages RAW264.7 induced by IL-4 and IL-13. Among these candidates, total flavonoids from Glycyrrhiza Radix et Rhizoma (TFRG) and ethanol extract of Ginseng Radix et Rhizoma significantly inhibited the expression of Arginase-1 (Arg-1) (above 90% at 100μg/mL), one of the phenotype markers of M2 macrophages. The inhibition of total saponins of Ginseng Radix et Rhizoma, ethanol extract of Cordyceps, ethanol extract of Acanthopanacis senticosi Radix et Rhizoma Seu caulis, and etha...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 15 February 2019Source: Gynecologic Oncology ReportsAuthor(s): Cecile Colpaert, Gerd Jacomen, Koen Van de Vijver, Marcella Baldewijns, Anne-Sophie Van Rompuy, Claire Bourgain, Jean-Christophe Noël, On behalf of the Belgian Working Group for Gynecological Pathology
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Abstract The combination of doxorubicin and cyclophosphamide commonly used to treat breast cancer can cause premature ovarian failure and infertility. α-Tocopherol is a potent antioxidant whereas γ-tocopherol causes apoptosis in a variety of cancer models in vitro including breast cancer. We hypothesised that the combination of doxorubicin (Dox) and 4-hydroperoxycyclophosphamide (4-Cyc) would be more cytotoxic in vitro than each agent alone, and that α-tocopherol would reduce and γ-tocopherol would augment the cytotoxicity of the combined chemotherapeutics. Human MCF-7 breast cancer and KGN...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
This article will discuss the epidemiology, mechanisms, diagnostic methods, and management of cardiotoxicity from systemic chemotherapy used to treat breast cancer.
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
ConclusionsBased on indirect comparisons, no differences in clinical outcomes were observed among diverse APBI techniques in published clinical trials that formally compared WBI to APBI. However wide confidence intervals and high risk of inconsistency precluded a sound conclusion. Further head-to-head clinical trials comparing different APBI techniques are required to confirm our findings. Studies comparing different techniques using individual participant data and/or real-life data from population-based studies/registries could also provide more robust results.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Our aim was to study the regulatory molecule networks involved in the epithelial-to-mesenchymal transition and thus promoting the early onset of metastasis in triple-negative breast cancer (TNBC). Forty pairs of human TNBC and their adjacent normal breast tissues were analyzed by real-time PCR and immunochemistry to demonstrate the correlation between the miR-205 expression and clinicopathological characteristics. In vitro, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay, cell migration, and invasion assay were used to detect the cell growth and invasive ability of TNBC cells after upregulation or d...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: PRECLINICAL REPORTS Source Type: research
In conclusion, our findings indicate that GPR120 acts as a cancer-promoting receptor in the development of breast cancer. Therefore, GPR120 is expected to be a potential new target for cancer therapy.
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: PRECLINICAL REPORTS Source Type: research
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