Impact of IFNL4- ∆G genotype on sustained virologic response in hepatitis C genotype 1 patients treated with direct-acting antivirals
In direct acting antiviral (DAA)-treated HCV genotype 1, the sustained virologic response rate with the ∆G/∆G genotype of IFNL4 rs368234815 (86.8%) was significantly lower than with ∆G/TT (95.9%, p=0.03) or TT/TT (98.6%, p=0.01). The SVR odds ratio for ∆G/∆G compared to TT/TT was 0.10 (p=0.03). IFNL4 genotype might predict DAA-response.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Lisa I. Backus, Troy A. Shahoumian, Pamela S. Belperio, Mark Winters, Ludmila Prokunina-Olsson, Thomas R. O'Brien, Mark Holodniy Tags: Note Source Type: research