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Neuraltus Pharmaceuticals Reports Results from Phase 2 NP001 Study in Amyotrophic Lateral Sclerosis (ALS)

SAN BRUNO, Calif. and LOS ANGELES, April 26, 2018 -- (Healthcare Sales &Marketing Network) -- Neuraltus Pharmaceuticals, Inc., a privately-held pharmaceutical company dedicated to developing innovative therapeutics for neurodegenerative diseases, today a... Biopharmaceuticals, Neurology Neuraltus Pharmaceuticals, Amyotrophic Lateral Sclerosis
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news

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Dongchao Shen, Bo Hou, Yinyan Xu, Bo Cui, Pan Peng, Xiaolu Li, Hongfei Tai, Kang Zhang, Shuangwu Liu, Hanhui Fu, Jing Gao, Mingsheng Liu, Feng Feng, Liying Cui
Source: Frontiers in Neurology - Category: Neurology Source Type: research
AbstractNeurological diseases, such as Parkinson ’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS) and multiple sclerosis, are often associated with functional gastrointestinal disorders. These gastrointestinal disturbances may occur at all stages of the neurodegenerative diseases, to such an extent that they are now consi dered an integral part of their clinical picture. Several lines of evidence support the contention that, in central neurodegenerative diseases, changes in gut microbiota and enteric neuro-immune system alterations could contribute to gastrointesinal dysfuncti...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
Patients with amyotrophic lateral sclerosis (ALS) who are hypermetabolic show greater functional decline and shorter survival, according to Australian researchers.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Reka P. Toth, Julie D. Atkin
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Semin Neurol 2018; 38: 176-181 DOI: 10.1055/s-0038-1649338“Stem cell tourism” is defined as the unethical practice of offering unproven cellular preparations to patients suffering from various medical conditions. This phenomenon is rising in the field of neurology as patients are requesting information and opportunities for treatment with stem cells for incurable conditions such as multiple sclerosis and amyotrophic lateral sclerosis, despite their clinical research and experimental designation. Here, we review the recent trends in “stem cell tourism” in both the United States and abroad, and discus...
Source: Seminars in Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
(Trinity College Dublin) Scientists have just discovered that a small region of a cellular protein that helps long-term memories form also drives the neurodegeneration seen in Amyotrophic Lateral Sclerosis (ALS).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Muscle&Nerve, EarlyView.
Source: Muscle and Nerve - Category: Internal Medicine Authors: Source Type: research
In this study, we detected AEG-1 expression in hSOD1G93A-positive (mut-SOD1) astrocytes and wild type (wt-SOD1) astrocytes, and intend to elucidate its potential functions in ALS related astrogliosis and the always accompanied dysregulated glutamate clearance. Results showed elevated protein and mRNA levels of AEG-1 in mut-SOD1 astrocytes; Also, NF-κB signaling pathway related proteins and inflammatory cytokines were upregulated in mut-SOD1 astrocytes; AEG-1 knockdown attenuated astrocytes proliferation and pro-inflammatory release; also we found that AEG-1 silence inhibited translocation of p65 from cytoplasma to nu...
Source: Molecular and Cellular Neuroscience - Category: Neuroscience Source Type: research
Amyotrophic lateral sclerosis (ALS) may have both spinal and bulbar manifestations, affects upper and lower limbs, resulting in respiratory insufficiency [1], difficulty gait and muscle paralysis [2]. In this way, functional alterations characterize ALS. Initially occurs in the lower limbs, progressing to the upper limbs until reaching the bulbar muscles [3]. This condition is often debilitating preventing the affected person of performing daily tasks on its own.
Source: Photodiagnosis and Photodynamic Therapy - Category: Laser Surgery Authors: Tags: Case report Source Type: research
Neurodegenerative diseases, such as Alzheimer ’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people every year and so far, there...
Source: Molecular Neurodegeneration - Category: Neurology Authors: Tags: Review Source Type: research
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