Progression and regression of fibrosis in viral hepatitis in the treatment era: the Beijing classification

Progression and regression of fibrosis in viral hepatitis in the treatment era: the Beijing classificationProgression and regression of fibrosis in viral hepatitis in the treatment era: the Beijing classification, Published online: 26 April 2018; doi:10.1038/s41379-018-0048-0Progression and regression of fibrosis in viral hepatitis in the treatment era: the Beijing classification
Source: Modern Pathology - Category: Pathology Authors: Source Type: research

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Authors: Zeng, Lin H, Cui J, Liang W Abstract Thymocyte selection-associated high mobility group box (TOX) genes represent a novel family of genes. Deregulated expression of TOXs has been reported in a variety of cancer types, including lung cancer. It has also been reported that TOXs are crucial regulators of the immune system. The present study systematically evaluated the prognostic values of TOX family members using a set of publicly accessible databases, including Oncomine, Kaplan-Meier plotter and cBioPortal. It was revealed that TOX expression profiles differed between lung cancer and normal tissues, and hig...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Onitsuka K, Tokuda R, Kuwata-Higashi N, Kumamoto H, Aoki M, Amano M, Kohgo S, Das D, Haraguchi K, Mitsuya H, Imoto S Abstract Hepatitis B virus (HBV) infection is a major worldwide health problem that requires the development of improved antiviral therapies. Here, a series of 4'-Azido-thymidine/4'-Azido-2'-deoxy-5-methylcytidine derivatives (6, 10-15) were synthesized, and their anti-HBV activities evaluated. Compounds 10-15 were synthesized via an SNAr reaction of 18, in which the 4-position of the thymine moiety was activated as the 2,4,6-triisopropylbenzenesulfonate. Compounds 11-15 showed no antiviral ...
Source: Nucleosides, Nucleotides and Nucleic Acids - Category: Biochemistry Tags: Nucleosides Nucleotides Nucleic Acids Source Type: research
Publication date: Available online 13 September 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Ignacio García-Juárez, Alejandro Campos-Murguía, Braulio A. Marfil-Garza, Godolfino Miranda, Edgar A. Granados, Rodrigo Ville
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Abstract Ethiopia's hepatitis virus (HCV) prevalence is predicted to rise by 2030. To halt this increasing trend, a suitable approach to the elimination of HCV is needed. This review explores the current status, challenges, and opportunities and outlines a strategy for the micro-elimination approach in Ethiopia. I searched PubMed and EMBASE using combined Medical Subject Heading databases for the literature on HCV micro-elimination. A phased public health approach to HCV micro-elimination, including preparation/capacity building (phase I), implementation (phase II), and rollout and scale-up (phase III), targeting ...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Publication date: Available online 13 September 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Xiaochen Yin, Xin Wang, Zhigang Zhang, Yufang Li, Zhijie Lin, Huirong Pan, Ying Gu, Shaowei Li, Jun Zhang, Ningshao Xia, Qinjian Zhao
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
ConclusionThe use of treatment regimens composed of SOF and DCV or SOF and SMV showed a high SVR rate, despite of a high rate of RAS, and a good tolerability profile in patients with HCV genotype 1. However, the high occurrence of baseline RAS observed in this casuistic is still a concern and studies like this show the necessity to understand how they are maintained in the population and to direct more efficiently the use of DAAs.
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
With one in every 20 Pakistanis already infected, Pakistan has the second largest number of hepatitis C virus (HCV) infections globally. The aim of this study was to present a quantitative and analytical chara...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
ConclusionWe believe that these efforts will help to significantly improve the gastrointestinal cancer treatment and survival.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
egini It is well known that hepatitis B virus reactivation (HBVr) can occur among patients undergoing treatment for hematological malignancies (HM). The evaluation of HBVr risk in patients undergoing immunosuppressive treatments is a multidimensional process, which includes conducting an accurate clinical history and physical examination, consideration of the virological categories, of the medication chosen to treat these hematological malignancies and the degree of immunosuppression induced. Once the risk of reactivation has been defined, it is crucial to adopt adequate management strategies (should reactivation occur...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Methamphetamine is involved in an increasing number of treatment admissions for heroin, especially among adolescents, astudy inAddiction has found.“The phenomenon of increasing methamphetamine use among people using opioids is of great concern,” Christopher M. Jones, Pharm.D., Dr.P.H., M.P.H., of the Centers for Disease Control and Prevention and colleagues wrote. “Methamphetamine use carries its own risks, including a range of physical and mental health consequences such as psychosis and other mental disorders; cognitive and neurologic deficits; cardiovascular and renal dysfunction; transmission of HIV, ...
Source: Psychiatr News - Category: Psychiatry Tags: addiction adolescents Christopher M. Jones heroin methamphetamine polysubstance use treatment Treatment Episode Data Set young adults Source Type: research
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