Clinical course of severe colitis: a comparison between Crohn ’s Disease and ulcerative colitis.

Clinical course of severe colitis: a comparison between Crohn’s Disease and ulcerative colitis. J Biol Regul Homeost Agents. 2018 Mar-Apr;32(2):415-423 Authors: Sinagra E, Orlando A, Scalisi A, Mocciaro F, Criscuoli V, Oliva L, Maisano S, Giunta M, La Seta F, Solina G, Rizzo AG, Leone A, Tomasello G, Cappello F, Cottone M Abstract Few data are available about the clinical course of severe colonic Crohn’s disease (CD). The aim of this study is to describe the clinical course of severe Crohn’s colitis in a patient cohort with isolated colonic or ileocolonic CD, and to compare it with the clinical course of patients with severe ulcerative colitis (UC). Thirty-four patients with severe Crohn’s colitis were prospectively identified in our cohort of 593 consecutive hospitalized patients through evaluation of the Crohn’s Disease Activity Index score and the Harvey-Bradshaw Index. One hundred sixty-nine patients with severe ulcerative colitis were prospectively identified in our cohort of 449 consecutive hospitalized patients through evaluation of the Lichtiger score and the Truelove-Witts score. We evaluated the following data/aspects: response to steroids, response to biologics, colectomy rate in acute, colectomy rate during follow-up, megacolon and cytomegalovirus infection rate. We did not find significant differences in the response to steroids and to biologics, in the percentage of cytomegalovirus infection and of megacolon, while...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research