Reactive oxygen species activate differentiation gene transcription of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway

Acute myeloid leukemia (AML) is a hematological malignancy that mainly originates from the bone marrow, with affected cells displaying myeloid characteristics. AML cells fail to undergo terminal differentiation and remain immature and proliferative. Process of terminal differentiation could be blocked by deregulation of transcription factors, such as RUNX1 and PU.1 (encoded by SPI-1 gene), that control myeloid differentiation. Mutations or reduced expression of these transcription factors were able to potentiate the development of AML [1,2].
Source: Leukemia Research - Category: Hematology Authors: Tags: Research paper Source Type: research