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The Economic Impact of New Therapeutic Interventions on Neuropsychiatric Inventory (NPI) Symptom Scores in Patients with Alzheimer Disease

Conclusion: Treatments that influence specific symptoms within the overall NPI have the potential to improve patient outcomes in a cost-effective way. This model is a useful tool for evaluating target product profiles of drugs with effect on NPI symptoms in early stages of development.Dement Geriatr Cogn Disord Extra 2018;8:158 –173
Source: Dementia and Geriatric Cognitive Disorders Extra - Category: Geriatrics Source Type: research

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I’m a little dumb-founded whenever I run across a prescribing trend that goes against all of the available empirical evidence for common sense use of a medication. Nowhere is this more evident than with the prescription of atypical antipsychotic medications. It wouldn’t be too far a stretch to suggest that such prescriptions have become like Prozac prescriptions in the 1990s, the latest medication fad. But atypical antipsychotics, like Seroquel (quetiapine fumarate), are far more complex with far more problematic side effects than drugs like Prozac, and should only be prescribed for on-label use. The Washingto...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic General Medications Policy and Advocacy Adverse Effects Atypical Antipsychotic Bipolar Disorder Insomnia movement disorder Seroquel side effects Weight Gain Source Type: blogs
According to the Alzheimer’s Association, “Today, someone in the United States develops Alzheimer’s every 65 seconds. By mid-century, someone in the United States will develop the disease every 33 seconds.” To date, there is no cure regarding this most common form of dementia, which affects nearly all individuals worldwide regardless of race, or socioeconomic status, a trend that continues to grow at a disturbingly alarming rate. Scientists however are close to identifying contributing factors that may hinder or help the progression of this illness in the long run. Listed below are the top 5 f...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Alzheimer's Health-related Memory and Perception Stress Alzheimer's disease Memory Loss Source Type: blogs
Authors: Grundy J, Mouzakis K, Vasa R, Cain A, Curumsing M, Abdelrazek M, Fernando N Abstract By the 2050, it is estimated that the proportion of people over the age of 80 will have risen from 3.9% to 9.1% of population of Organisation for Economic Cooperation and Development countries. A large proportion of these people will need significant help to manage various chronic illnesses, including dementia, heart disease, diabetes, limited physical movement and many others. Current approaches typically focus on acute episodes of illness and are not well designed to provide adequately for daily living care support. In o...
Source: Studies in Health Technology and Informatics - Category: Information Technology Tags: Stud Health Technol Inform Source Type: research
Abstract BACKGROUND: The accurate clinical characterisation of mild cognitive impairment (MCI) is becoming increasingly important. The aim of this study was to compare the neuropsychiatric symptoms and cognitive profile of MCI with Lewy bodies (MCI-LB) with Alzheimer's disease MCI (MCI-AD). METHODS: Participants were ⩾60 years old with MCI. Each had a thorough clinical and neuropsychological assessment and 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computed tomography FP-CIT SPECT). MCI-LB was diagnosed if two or more diagnostic features of dementia with...
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Introduction: Patients with Alzheimer's Disease, besides cognitive problems, can also show many behavioral and psychological problems, which are known as BPSD (Behavioral and Psychological Symptom of Dementia). BPSD consists of sleep wake rhythm disorders, hallucinations, depressive mood, anxiety, odd behavior like wandering, restlessness, agitation, sexual disinhibition and cursing. Some studies highlighted that about 64% of patients with Alzheimer's presents with at leas tone of those symptoms at their first clinical evaluation.
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: Behavior, Cognition and Dreaming Source Type: research
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research
CONCLUSION: Findings suggest that sleep disturbance, depression, and anxiety are associated with AD development among cognitively asymptomatic participants. Decreasing the threat posed by psychological symptoms may be one avenue for possibly delaying onset of AD. PMID: 29077487 [PubMed - as supplied by publisher]
Source: Aging and Mental Health - Category: Geriatrics Authors: Tags: Aging Ment Health Source Type: research
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion. A review of the literature suggests that there are adequate data supporting the efficacy and general safety of the low-dose use of trazodone for the treatment of insomnia. keywords: insomnia, hypnotics, treatment, trazodone, sedative Keywords: insomnia, hypnotics, treatment, trazodone, sedative Innov Clin Neurosci. 2017;14(9–10):24–34 Introduction Insomnia is characterized by difficulty falling asleep, difficulty staying asleep, or waking too early1 and is associated with significant impairments in daytime activities, which might occur despite adequate opportunities for sleep.2–6 Primary insom...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review hypnotics insomnia sedative trazodone treatment Source Type: research
Every caregiver of a person living with Alzheimer's, Lewy Body dementia, Parkinson's or any other related dementia faces this gut wrenching question -Should I put my loved with dementia in a nursing home or memory care facility?By Bob DeMarcoAlzheimer's Reading RoomWe all face this gut wrenching decision. Most of us don't want to do it. But sometimes, it is the only decision, and only right decision.There are a long list of reasons why you might have to place your loved one in a nursing home or long term care memory facility.Topic -Dementia CareLet me start by making this clear -it is not your fault.It is not your fault th...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's care facilities care of dementia patients caregiver dementia care elderly dementia care help alzheimer's help with dementia care memory care facilities memory care facility nursing home Source Type: blogs
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