Drug susceptibility profile of Candida glabrata clinical isolates from Iran and genetic resistant mechanisms to caspofungin.

CONCLUSIONS: The silent mutations in the hotspot areas of FKS genes and inconsiderable changes in gene expression were not associated with increased MIC (0.25μg/ml). Other mechanisms of resistance which include mutations outside the hotspot area of FKS genes could be involved in a slight increase of MIC, and they should be identified through complete FKS gene sequencing. PMID: 29685375 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29685375?dopt=Abstract

Source: Revista Iberoamericana de Micologia - April 20, 2018 Category: Biology Authors: Amanloo S, Shams-Ghahfarokhi M, Ghahri M, Razzaghi-Abyaneh M Tags: Rev Iberoam Micol Source Type: research