NADPH oxidase, oxidative stress and fibrosis in Systemic Sclerosis.

NADPH oxidase, oxidative stress and fibrosis in Systemic Sclerosis.
Free Radic Biol Med. 2018 Apr 22;:
Authors: Svegliati S, Spadoni T, Moroncini G, Gabrielli A
Abstract
Systemic sclerosis (SSc) is an autoimmune disease characterized by damage of small vessels, immune abnormalities and exaggerated production of extracellular matrix. The etiology of the disease is unknown and the pathogenesis ill defined. However, there is consistent evidence that oxidative stress contributes to the establishment and progression of the disease. This review examines the most relevant research regarding the involvement of free radicals and of nicotinamide adenine dinucleotide phosphate oxidases (NADPH oxidases; NOX) in the pathogenesis of systemic sclerosis.
PMID: 29694853 [PubMed - as supplied by publisher]

Source: Free Radical Biology and Medicine - April 22, 2018 Category: Biology Authors: Svegliati S, Spadoni T, Moroncini G, Gabrielli A Tags: Free Radic Biol Med Source Type: research