Inhibiting IL-2 signaling and the regulatory T-cell pathway using computationally designed peptides

Conclusions We conclude that structure-based peptide design can be used to identify novel peptide inhibitors that block IL-2/sIL-2R α signaling and inhibit Treg cell development. We anticipate that these peptides will have therapeutic potential in B-cell NHL and other malignancies.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research