Adeno-Associated Virus Gene Therapy: Translational Progress and Future Prospects in the Treatment of Heart Failure
Despite advances in treatment over the past decade, heart failure remains a significant public health burden and a leading cause of death in the developed world. Gene therapy provides a promising approach for preventing and reversing cardiac abnormalities, however, clinical application has shown limited success to date. A substantial effort is being invested into the development of recombinant adeno-associated viruses (AAVs) for cardiac gene therapy as AAV gene therapy offers a high safety profile and provides sustained and efficient transgene expression following a once-off administration.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Sebastian Bass-Stringer, Bianca C. Bernardo, Clive N. May, Colleen J. Thomas, Kate L. Weeks, Julie R. McMullen Tags: Review Source Type: research
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