Dofetilide dose reductions and discontinuations in women compared with men

Compared with men, women have longer corrected QT (QTc) intervals, lower clearance of dofetilide, and higher rates of drug-induced torsades de pointes, but the dofetilide dosing algorithm is the same for men and women.

Source: Heart Rhythm - April 1, 2018 Category: Cardiology Authors: Sean D. Pokorney, Debbie C. Yen, Kristen B. Campbell, Nancy M. Allen LaPointe, Shubin Sheng, Laine Thomas, Tristram D. Bahnson, James P. Daubert, Jonathan P. Picini, Kevin P. Jackson, Kevin L. Thomas, Sana M. Al-Khatib Tags: Featured Article Source Type: research