Gliadin-related antibodies in schizophrenia

Gluten sensitivity (GS), a distinctly different immune response from celiac disease (CD), is believed to be associated with neurologic and psychiatric manifestations. Schizophrenia has been linked to enhanced immune reactivity to gluten (Jackson et al., 2012b). Recently, the production of AGA IgG antibodies has been proposed as a marker of GS. AGA IgG in schizophrenia have been associated with increased peripheral (Demyanovich et al., 2017) and central immune reactions (Rowland et al., 2017), and lower positive symptom scores as measured by the Brief Psychiatric Rating Scale (Jackson et al., 2014), suggesting that an AGA IgG positive population of schizophrenia could be a distinct subgroup.

Source: Schizophrenia Research - September 5, 2017 Category: Psychiatry Authors: Daniela Čiháková, William W. Eaton, Monica V. Talor, Uasim H. Harkus, Haley K. Demyanovich, Katrina Rodriguez, Stephanie Feldman, Deanna L. Kelly Tags: Letter to the Editor Source Type: research