The relation of vitamin D, metabolic risk and negative symptom severity in people with psychotic disorders

People with psychotic disorders have an increased metabolic risk and their mean life expectancy is reduced with circa 28years (Olfson et al., 2015).Predictors of this increased metabolic risk are genetic predisposition (Liu et al., 2013), lifestyle factors such as unhealthy diet, physical inactivity and smoking (Bobes et al., 2010), and the side effects of antipsychotic medication (Werner and Cove ñas, 2014;Chadda et al., 2013). Low vitamin D status might also contribute to an increased metabolic risk (Ginde et al., 2009;Kendrick et al., 2009;Kilkkinen et al., 2009;Ford et al., 2009) and all-cause mortality by promoting atherosclerosis, hypertension, inflammation and activation of the renin- angiotensin system (Wang et al., 2012;Garland et al., 2014;Lee et al., 2008).

Source: Schizophrenia Research - September 16, 2017 Category: Psychiatry Authors: J. Bruins, F. J örg, E.R. van den Heuvel, A.A. Bartels-Velthuis, E. Corpeleijn, F.A.J. Muskiet, G.H.M. Pijnenborg, R. Bruggeman Source Type: research