Schizophrenia in Wolfram Syndrome (DIDMOAD Syndrome): A case report in support of the mitochondrial dysfunction hypothesis

Schizophrenia is a chronic severe disabling psychiatric illness of neurodevelopmental origin with a lifetime prevalence of 1% (Saha et al., 2005). It is highly heritable and considered as a polygenic disorder whose origin or cause is still not clear (Cardno et al., 1999; Gottesman and Shields, 1967). Though it is considered to be a brain disorder, studies have shown that patient with schizophrenia may have various systemic abnormalities. Ultra-structural changes in the mitochondria have led to a proposal of Mitochondrial dysfunction as one of the promising pathways for the pathogenesis of schizophrenia (Park and Park, 2012; Somerville et al., 2011).

Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Guru S. Gowda, Dev Rai, Ravi Kumar Nadella, Sarbesh Tiwari, Ravi Yadav, Suresh Bada Math Tags: Letter to the Editor Source Type: research