Genetic analysis of deep phenotyping projects in common disorders

Several studies of complex psychotic disorders with large numbers of neurobiological phenotypes are currently under way, in living patients and controls, and on assemblies of brain specimens. Genetic analyses of such data typically present challenges, because of the choice of underlying hypotheses on genetic architecture of the studied disorders and phenotypes, large numbers of phenotypes, the appropriate multiple testing corrections, limited numbers of subjects, imputations required on missing phenotypes and genotypes, and the cross-disciplinary nature of the phenotype measures.

Source: Schizophrenia Research - October 20, 2017 Category: Psychiatry Authors: Elliot S. Gershon, Godfrey Pearlson, Matcheri S. Keshavan, Carol Tamminga, Brett Clementz, Peter F. Buckley, Ney Alliey-Rodriguez, Chunyu Liu, John A. Sweeney, Sarah Keedy, Shashwath A. Meda, Neeraj Tandon, Rebecca Shafee, Jeffrey R. Bishop, Elena I. Ivle Source Type: research