Aberrant corticostriatal connectivity predict positive symptoms of antipsychotic-na ïve patients with adolescent-onset schizophrenia during brain maturation

Patients with childhood- and adolescent-onset schizophrenia are thought to have severe clinical symptoms and age-related deviance in attention, memory, and executive function (Frangou, 2010). Given that early dopaminergic dysregulation in the striatum and cortical regions may be associated with the emergence of psychotic symptoms (Murray et al., 2008; Simpson et al., 2010), investigations into the corticostriatal circuits in adolescent patients may provide an exceptional opportunity to explore the pathogenesis of schizophrenia during brain maturation (Simpson et al., 2010).
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the Editor Source Type: research