The use of polygenic risk scores to identify phenotypes associated with genetic risk of schizophrenia: Systematic review
Studying the phenotypic manifestations of increased genetic liability for schizophrenia can increase our understanding of this disorder. Specifically, information from alleles identified in genome-wide association studies can be collapsed into a polygenic risk score (PRS) to explore how genetic risk is manifest within different samples. In this systematic review, we provide a comprehensive assessment of studies examining associations between schizophrenia PRS (SZ-PRS) and several phenotypic measures.
Source: Schizophrenia Research - Category: Psychiatry Authors: Sumit Mistry, Judith R. Harrison, Daniel J. Smith, Valentina Escott-Price, Stanley Zammit Source Type: research