Meta-analysis on the association between genetic polymorphisms and prepulse inhibition of the acoustic startle response

Sensorimotor gating measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) has been proposed as one of the most promising electrophysiological endophenotypes of schizophrenia. During the past decade, a number of publications have reported significant associations between genetic polymorphisms and PPI in samples of schizophrenia patients and healthy volunteers. However, an overall evaluation of the robustness of these results has not been published so far. Therefore, we performed the first meta-analysis of published and unpublished associations between gene polymorphisms and PPI of ASR.

Source: Schizophrenia Research - December 26, 2017 Category: Psychiatry Authors: Boris B. Quednow, Kenechi Ejebe, Michael Wagner, Stella G. Giakoumaki, Panos Bitsios, Veena Kumari, Panos Roussos Source Type: research