Aberrant cerebellar-default-mode functional connectivity underlying auditory verbal hallucinations in schizophrenia revealed by multi-voxel pattern analysis of resting-state functional connectivity MRI data

Auditory verbal hallucinations (AVH) are common in patients with schizophrenia. Previous functional magnetic resonance imaging (fMRI) studies have repeatedly suggested that critical abnormalities underlying AVH are not entirely confined to particular brain regions or functional networks but rather involve functional connectivity (FC) among brain regions dispersed across multiple functional systems (Alonso-Solis et al. 2017; Cui et al. 2017). However, conventional FC analyses, such as seed-based correlation analysis and independent component analysis, typically restrict targets of investigation to specific seed regions or functional networks.
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the Editor Source Type: research

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Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
This study aimed to determine if results from in vivo studies could be replicated on a post-mortem cohort of decedents who suffered from severe mental illness. We included 96 decedents with either schizophrenia (n = 34), depressive disorder (n = 17), or no known psychiatric diagnosis (n = 45) from April 2015 to January 2017. All cases underwent a T2-weighted cerebral MRI less than 24 h before autopsy. We used a manual segmentation algorithm to define the hippocampus on coronal images and subsequently estimate the volume of the region. The group with schizophrenia had a statis ...
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Source: Journal of Medical Systems - Category: Information Technology Source Type: research
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Source: Psychopharmacology - Category: Psychiatry Source Type: research
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Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
CONCLUSIONS: The findings of the study revealed a wide range of thalamic functional dysconnectivity in the CCTCC pathway, increasing our understanding of the relationship between the CCTCC pathway and symptoms associated with schizophrenia, and further indicating a potential alteration pattern in the thalamic nuclei in people with schizophrenia.Declaration of interestNone. PMID: 30791964 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
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Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
(NIH/National Institute of Mental Health) Researchers have shown that a type of magnetic resonance imaging -- called neuromelanin-sensitive MRI (NM-MRI) -- is a potential biomarker for psychosis. NM-MRI signal was found to be a marker of dopamine function in people with schizophrenia and an indicator of the severity of psychotic symptoms in people with this mental illness. The study was funded, in part, by the National Institute of Mental Health (NIMH), part of the National Institutes of Health.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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